Intestinal innate immune barrier and genetic regulatory mechanisms employed by enteropathogenic bacteria to evade innate immune system in intestines
10.16303/j.cnki.1005-4545.2024.06.26
- VernacularTitle:肠道固有免疫屏障与致病菌逃避肠道固有免疫清除的基因调控策略
- Author:
Sijia LI
1
;
Siqi LIAN
;
Li YAN
;
Pengpeng XIA
Author Information
1. 扬州大学兽医学院比较医学研究院江苏省动物重要疫病与人兽共患病防控协同创新中心/江苏高校动物重要疫病和重要人兽共患病防控技术国际合作联合实验室,江苏扬州 225009
- Keywords:
enteropathogenic bacteria;
intestinal innate immunity;
gene regulation;
quorum sensing
- From:
Chinese Journal of Veterinary Science
2024;44(6):1299-1306,1315
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal pathogenic bacteria utilize their own virulence factors to interfere with the nor-mal function of intestinal epithelial cells and evade clearance by the host immune system through precise gene regulation and expression strategies,thereby causing a variety of diseases.It has been found that the mechanisms affecting the gene expression strategies of pathogens include the toxin-antitoxin system,secretory system,and quorum sensing system.Novel antimicrobial strategies are being developed to interfere with the inherent gene regulatory system of bacteria and inhibit the expression of virulence genes,thus enabling a modest approach to the treatment of intestinal disea-ses.This paper initially discusses the components of innate immunity in the gut,followed by a dis-cussion of the common gene regulatory system of intestinal pathogenic bacteria.This article aims to clarify the mechanisms by which intestinal pathogenic bacteria evade clearance by the innate im-mune system through gene regulation and expression strategies,and to provide new ideas for the treatment of intestinal bacterial diseases.
