Research progress on the evaluation and intervention of social interaction behaviors in animal models of autism

VernacularTitle:自闭症动物模型社会互动行为的评估及干预研究进展
Author: Minghui KONG ¹ ; Liming LU ; Leiying XIANG ; Xiaoyi CHEN ; Zhiru ZHU
Author Information

1. 重庆师范大学教育科学学院,重庆 401331
Keywords: autism spectrum disorder; three-compartment social interaction test; behavioral experiment; oxytocin
From: Chinese Journal of Comparative Medicine 2024;34(10):169-178
CountryChina
Language:Chinese
Abstract: Autism spectrum disorder(ASD)is a highly heterogeneous neurodevelopmental disorder with a complex underlying genetic structure.Current preclinical trials,however,mainly rely on rodent models to test the effects of non-pharmacological and pharmacological interventions on the core and related symptoms of ASD.This paper considers the brain regions that affect social interaction behaviors from the perspective of cognitive neural mechanisms,and reviews behavioral testing experiments,such as the three-chamber social interaction test,visible burrow system,and eco-HAB system.We also summarize effective non-pharmacological and pharmacological interventions,such as baclofen,oxytocin,and metformin,in the core and related symptom areas of ASD.This review aims to provide reference directions to promote the development of preclinical trials using rodent models.