Research progress on Wnt/β-catenin signaling pathway in programmed cell death after ischemic stroke
10.3969/j.issn.1671-7856.2024.10.017
- VernacularTitle:Wnt/β-catenin信号通路在缺血性脑卒中后程序性细胞死亡中作用的研究进展
- Author:
Rui PAN
1
;
Ming ZHANG
;
Xinyue ZHENG
;
Chunxiao WANG
;
Qiongdi REN
Author Information
1. 河南中医药大学康复医学院,郑州 450046
- Keywords:
ischemic stroke;
Wnt/β-catenin signaling pathway;
cell apoptosis;
pyroptosis;
review
- From:
Chinese Journal of Comparative Medicine
2024;34(10):138-145
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a neurological disease that damages brain tissue as a result of an insufficient blood supply to the brain,due to blockage or stenosis of the brain vessels.Increasing evidence has indicated that the Wnt/β-catenin signaling pathway plays an important role in the pathophysiological response to the occurrence and development of ischemic stroke.Programmed cell death includes many forms,such as apoptosis,necrotic apoptosis,pyroptosis,autophagy,PANoptosis,and ferroptosis.In this review,we elucidate the characteristics of these different modes of cell death and their cross-talk relationships with each other,and systematically outline the role of Wnt/β-catenin signaling pathways in the intervention of different cell death modes in ischemic stroke,with the aim of providing references for future clinical and basic research studies.
