Research advances in the pathogenesis of abnormal copper metabolism in Parkinson's disease
10.3969/j.issn.1671-7856.2024.10.015
- VernacularTitle:铜代谢异常在帕金森发病机制中的研究进展
- Author:
Huijie YANG
1
;
Rui LAN
;
Manman WANG
;
Weiwei WANG
;
Hongyu LI
;
Chen TANG
;
Shuang LIU
;
Jieli YANG
;
Xiaoming SHEN
Author Information
1. 河南中医药大学第一附属医院脑病中心,郑州 450000
- Keywords:
Parkinson's disease;
copper metabolism;
oxidative stress;
α-synuclein;
ceruloplasmin;
mitochondrial dysfunction
- From:
Chinese Journal of Comparative Medicine
2024;34(10):118-124
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease is a neurodegenerative disease associated with abnormal copper metabolism in the brain,which leads to misfolding and aggregation of α-synuclein-copper complexes,which is an important pathological sign of Parkinson's disease.Copper metabolism,i.e.,cellular metabolic processes involving copper ions,is closely related to the pathogenesis of α-synuclein aggregation,dopamine metabolism,mitochondrial dysfunction,oxidative stress,and ferroptosis in Parkinson's disease.In this review,we summarize the molecular metabolic mechanism of copper toxicity by studying the pathological role of copper metabolism in Parkinson's disease,to support our further understanding of the mechanism of action and drug development.
