Research progress on the mechanism of D-galactose-induced brain aging model

VernacularTitle:D-半乳糖诱导脑老化模型机制的研究进展
Author: Ziyue ZHU ¹ ; Meiling JIN ; Xiangyue XU ; Qing LIU ; Jiaxue ZHU ; Mingjun FU ; Xia LEI ; Ning ZHANG
Author Information

1. 黑龙江中医药大学基础医学院,哈尔滨 150040
Keywords: brain aging; D-galactose; model mechanism
From: Chinese Journal of Comparative Medicine 2024;34(10):104-110,117
CountryChina
Language:Chinese
Abstract: As a normal physiological substance,D-galactose can induce a process similar to natural brain aging in vivo and in vitro when administered excessively,and thus it is widely used to induce brain aging models in China and abroad.The model of brain failure induced by D-galactose has the advantages of a short modeling time,low cost,and significant effect.However,the induction mechanisms are complex and diverse,and the relationships between the mechanisms are unclear,which limit the practical applications of the model.This article reviews the in vivo metabolism of D-galactose and the various mechanisms involved in the induction of brain aging,as well as the links between the mechanisms,to provide a reference for the application and development of this model and the in-depth study of brain aging.