Research progress on macrophage metabolism and immune function in coronary heart disease with phlegm and blood stasis syndrome
10.3969/j.issn.1671-7856.2024.09.018
- VernacularTitle:冠心病痰瘀互结证中巨噬细胞代谢与免疫作用研究进展
- Author:
Panxia CAO
1
;
Zining PENG
;
Jian LI
;
Hong WU
Author Information
1. 河南中医药大学第二临床医学院,郑州 450002
- Keywords:
macrophages;
energy metabolism;
coronary heart disease with phlegm and blood stasis syndrome;
immune regulation
- From:
Chinese Journal of Comparative Medicine
2024;34(9):157-164
- CountryChina
- Language:Chinese
-
Abstract:
In traditional Chinese medicine,coronary heart disease falls under the categories of"chest impediment and heart pain"and"true heart pain",with lipid metabolism disorder and the inflammatory response acting as biochemical manifestations of"phlegm and stasis"throughout the disease.The energy metabolism of macrophages is closely related to their immune function and is an important factor in regulating the metabolic disorder and inflammatory responses in coronary heart disease.This article reviews the role of macrophages in the pathophysiology of coronary heart disease.We discuss how these metabolic pathways affect the immune responses of macrophages and influence the disease.We delve into the different modes of macrophage energy metabolism in coronary heart disease,especially the metabolic characteristics and immune regulatory functions of pro-inflammatory M1 and anti-inflammatory M2 macrophages in the syndrome of phlegm and blood stasis.This provides a theoretical guidance for understanding the pathogenic mechanism of the syndrome of phlegm and blood stasis in coronary heart disease and developing new treatment strategies.
