Research progress on the AMPK signaling pathway-based pharmacological mechanism of traditional Chinese medicine in the treatment of cerebral ischemia-reperfusion injury
10.3969/j.issn.1671-7856.2024.09.015
- VernacularTitle:基于调控AMPK信号通路的中药治疗脑缺血再灌注损伤药理机制研究进展
- Author:
Chenfei HE
1
,
2
;
Chiyuan MA
;
Chunlong RAN
;
Haoge CHENG
;
Shu ZHANG
;
Senyu WANG
;
Hanlin YU
;
Xiangzhe LIU
Author Information
1. 河南中医药大学第一附属医院脑病中心,郑州 450000
2. 河南中医药大学第一临床医学院,郑州 450046
- Keywords:
traditional Chinese medicine;
AMPK signaling pathway;
cerebral ischemia-reperfusion injury;
research progress
- From:
Chinese Journal of Comparative Medicine
2024;34(9):127-136
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion injury(CIR1)refers to the recovery of blood supply after cerebral ischemia,which leads to further damage and the dysfunction of brain tissue.Modern medicine has made some progress in the prevention and treatment of CIRI,but it still faces some challenges and limitations.Therefore,it is of great clinical value to find effective interventions to prevent and treat CIRI.AMP-activated protein kinase(AMPK)and its downstream proteins are important targets for the treatment of CIRI and play key roles in the regulation of cellular energy homeostasis.Traditional Chinese medicine for CIRI has multi-target and multi-pathway activities and multiple effects.It can activate a cascade of reactions in the AMPK signaling pathway and can be used to treat CIRI by regulating autophagy,oxidative stress,inflammatory response,and apoptosis,and has achieved certain result.Therefore,this paper summarizes the structure and mechanisms of the AMPK-related signaling pathway,elaborates on its relationship with CIRI,and systematically summarizes the research status of traditional Chinese medicine's ability to regulate the AMPK signaling pathway in the prevention and treatment of CIRI.This paper aims to provide new ideas for the prevention and treatment of CIRI using traditional Chinese medicine and the development of new drugs.
