Research progress in diarrhea animal models and drug therapies

VernacularTitle:腹泻动物模型及治疗药物研究进展
Author: Yucun SHI ^{1
,

2} ; Xiaoli DONG ; Xiaoying HOU ; Kai YIN ; Fan GAO ; Guotai WU
Author Information

1. 甘肃中医药大学药学院,兰州 730000
2. 陇药产业创新研究院,兰州 730000
Keywords: diarrhea; animal model; drug therapy; research progress
From: Chinese Journal of Comparative Medicine 2024;34(9):94-107
CountryChina
Language:Chinese
Abstract: Diarrhea is a common and frequent disease in clinical practice.Many factors cause diarrhea,and numerous research method with animal models of diarrhea have been explored.Despite this,drugs for the treatment of diarrhea in clinical practice are limited,and some existing drugs are only suitable for diarrhea caused by a single factor.Therefore,the construction and selection of appropriate animal models of diarrhea are not only important for in-depth studies of the pathogenesis,but are also effective means for the clinical screening and evaluation of drugs for comprehensively preventing and treating diarrhea.This article reviews the literature on the establishment and evaluation of animal models of functional,bacterial,viral,and symptomatic diarrhea,as well as progress of therapeutic drug research,to provide a reference for animal experimental research into the prevention and treatment of diarrhea.