Analysis of blood physiological and biochemical indicators of spontaneous type 2 diabetes in inbred SHANXI MU Chinese hamsters
10.3969/j.issn.1671-7856.2024.09.003
- VernacularTitle:近交系自发性2型糖尿病中国地鼠山医群体血液生理生化指标的检测分析
- Author:
Yuting YANG
1
,
2
;
Yichun YANG
;
Bingyan WEI
;
Jianqin WU
;
Ruihu ZHANG
;
Zhaoyang CHEN
Author Information
1. 山西医科大学实验动物中心,太原 030001
2. 山西省实验动物与人类疾病动物模型重点实验室,太原 030001
- Keywords:
Chinese hamster;
type 2 diabetes;
physiological indexes;
biochemical indexes
- From:
Chinese Journal of Comparative Medicine
2024;34(9):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the blood physiological and biochemical indexes in the inbred SHANXI MU strain of spontaneous type 2 diabetes(T2DM)Chinese hamsters.Methods Chinese hamsters with spontaneously developed T2DM and normal hamsters(n=10 hamsters per group),aged 12 months,were selected for the study.Fasting blood samples were collected and 15 physiological parameters and 16 biochemical indicators were analyzed using a Sysmex XT automated hematology analyzer and Hitachi fully automatic biochemical analyzer.Results The white cell count,red cell count,platelet count,hemoglobin level,alanine transaminase,aspartate transaminase,glutamate,total cholesterol,triglycerides,and uric acid all differed significantly between the diabetic and control groups(P＜0.05).Conclusions The change of blood physiological and biochemical indexes in the Chinese hamster spontaneous T2DM model were in line with the trend in human T2DM incidence,thus providing basic data for the application of this model.
