Analysis of animal model of psoriatic arthritis based on Chinese and Western medicine characteristics
10.3969/j.issn.1671-7856.2024.08.018
- VernacularTitle:基于中西医临床病证特点的银屑病性关节炎动物模型分析
- Author:
Yajin SHI
1
;
Hanbing LI
;
Genlin LI
;
Suhui WU
Author Information
1. 河南中医药大学,河南省健康衰老产业工程研究中心,郑州 450046
- Keywords:
psoriatic arthritis;
clinical characteristics;
animal model;
coincidence degree
- From:
Chinese Journal of Comparative Medicine
2024;34(8):156-166
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,psoriatic arthritis has become a major problem in the medical field,with cases gradually increasing in China,and it is still incurable.Here,we summarize the pathogenesis and clinical characteristics of currently available animal models of psoriatic arthritis based on Chinese and Western medical evidence.Literature in line with this topic was collated and summarized.The etiology and pathogenesis according to Chinese and Western medicine of existing psoriatic arthritis models were given agreement scores;the diagnostic criteria of Chinese and Western medicine were compared;and the models'characteristics and degree of agreement with clinical observations were assessed.This study found that the human leukocyte antigen transgenic mouse model,the multiple hybridization transgenic mouse model,and the mannan-induced mouse model had the highest agreement scores.As psoriatic arthritis is more common in Europe,methods for the preparation of animal models have been mostly imported from abroad,and very few animal models have the characteristics of Chinese medicine;therefore,the model fitness scores of Western diagnoses were higher than those of Chinese diagnoses as a whole.We hope to leverage the unique diagnosis and treatment method of Chinese medicine further to improve the types of psoriatic arthritis animal models available.This study provides a basis for the construction of improved animal models of psoriatic arthritis with combined traditional Chinese and Western medicine characteristics.
