Role of NLRP3-pyroptosis in experimental sepsis-induced lung injury
10.3969/j.issn.1671-7856.2024.08.016
- VernacularTitle:NLRP3-细胞焦亡在实验性脓毒症肺损伤中的作用
- Author:
Yuting LI
1
;
Chunyu NIU
;
Zigang ZHAO
Author Information
1. 河北北方学院基础医学院&微循环研究所,张家口 075000
- Keywords:
Nod-like receptor pyrin domain-associated protein 3;
pyroptosis;
sepsis;
lung injury
- From:
Chinese Journal of Comparative Medicine
2024;34(8):139-147
- CountryChina
- Language:Chinese
-
Abstract:
The Nod-like receptor pyrin domain-associated protein 3(NLRP3)-mediated pyroptosis of pulmonary parenchymal and immune cells plays a key role in the pathogenesis of lung injury during sepsis.NF-κB,JAK2/STAT3 and MAPK signaling pathways are involved in NLRP3-mediated pyroptosis.Targeting NLRP3-pyroptosis and its related signaling pathways,pharmacological interventions with Physalin B,schisandrin,erythropoietin,and physical therapies such as acupuncture at Zusanli and Feishu points,as well as NLRP3-specific inhibitors like ergolide,have all shown effective anti-septic effects in treating lung injuries.This article reviewed the roles and mechanisms of NLRP3-pyroptosis in sepsis-induced lung injury,as well as the experimental progresses made in targeting NLRP3 pyroptosis as a therapy.We aim to highlight the importance of NLRP3-pyroptosis as a target,providing insights for the prevention and treatment of sepsis-induced lung injury.
