Research progress on the mechanism of action of Morinda officinalis oligosaccharides on depression

VernacularTitle:巴戟天寡糖抗抑郁作用机制的研究进展
Author: Mengjie HE ¹ ; Xueling DAI ; Qing HUO ; Xin LI
Author Information

1. 北京联合大学生物活性物质与功能食品北京市重点实验室,北京 100191
Keywords: Morinda officinalis oligosaccharides; depression; mechanism of action
From: Chinese Journal of Comparative Medicine 2024;34(8):107-114
CountryChina
Language:Chinese
Abstract: Depression is a psychosomatic disorder.The rising incidence rate of depression in recent years is placing a heavy economic burden on societies around the world.Morinda officinalis oligosaccharides(MOOs)are active substances extracted from the Chinese herb Morinda officinalis that can soothe depression and calm the mind,tonify the kidneys,and benefit the intellect,as well as improve cognitive disorders in patients to a certain extent.On the basis of the hypothesised pathological mechanism of depression,this study explains the link between MOOs and depression by reviewing existing studies.We propose that MOOs can improve depression through mechanisms that regulate the levels of monoamine neurotransmitters,enhance neuroplasticity,regulate the function of the HPA axis and levels of cytokines,and influence gut microbiota.This paper provides new ideas for research on the antidepressant effects of MOOs.