Ferroptosis and its role during experimental acute lung injury
10.3969/j.issn.1671-7856.2024.08.012
- VernacularTitle:铁死亡及其在实验性急性肺损伤中的作用
- Author:
Huanrong GUO
1
;
Jing WANG
;
Zigang ZHAO
;
Chunyu NIU
Author Information
1. 河北北方学院基础医学院/微循环研究所,河北 张家口 075000
- Keywords:
ferroptosis;
glutathione peroxidase 4;
lipid peroxidation;
acute lung injury
- From:
Chinese Journal of Comparative Medicine
2024;34(8):99-106
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a non-apoptotic mode of cell death characterized by iron-dependent lipid-peroxide-accumulation-induced membrane lipid peroxidation and mitochondrial atrophy.It differs from other programmed cell deaths in its morphological and biochemical properties.Ferroptosis is regulated by a variety of metabolic pathways that are involved in the acute lung injury induced by hemorrhagic shock,ischemia-reperfusion,sepsis,and radiation.This article reviews the main regulatory mechanisms of ferroptosis and its role in the pathogenesis of acute lung injury in various animal models with the aim of providing new strategies for the prevention and treatment of acute lung injury.
