Characterization of the immune microenvironment and immunotherapy for cholangiocarcinoma:mechanisms,challenges,and prospects

VernacularTitle:胆管癌免疫微环境特征与免疫治疗:机制、挑战与前景
Author: Zehan LIU ^{1
,

2} ; Shuangqing LIU ; Xueliang WU ; Qin YANG ; Xiaojun SUI
Author Information

1. 成都市第三人民医院普外科肝胆胰病区,西南交通大学附属医院&重庆医科大学附属成都第二临床医学院,成都 610031
2. 天津医科大学南开临床学院,天津 300100
Keywords: cholangiocarcinoma; immune microenvironment; immunotherapy; clinical study
From: Chinese Journal of Comparative Medicine 2024;34(7):168-174
CountryChina
Language:Chinese
Abstract: Cholangiocarcinoma is a malignant tumor with biliary epithelial features.The early diagnosis of cholangiocarcinoma is currently difficult and the treatment outcomes are poor.Its microenvironment includes abundant fibrotic mesenchyme and a variety of cell types,which promote the development and metastasis of cholangiocarcinoma by interacting with tumor cells through mechanisms such as facilitating migration,suppressing the immune response,and inducing angiogenesis and lymphangiogenesis.Immunotherapy is an important tumor treatment approach,and immunotherapy for cholangiocarcinoma has made some progress.This article reviews the characteristics of the immune microenvironment of cholangiocarcinoma,its relationship with immunotherapy,and cutting-edge therapeutic strategies.