Effects of ezrin protein on Helicobacter pylori-induced nodular gastritis

VernacularTitle:Ezrin蛋白在幽门螺杆菌感染的结节性胃炎中的研究进展
Author: Peng WANG ^{1
,

2} ; Hongwei ZHU ; Shuyuan JIANG ; Xiaolei LIU ; Bing GAO ; Guo SHAO
Author Information

1. 包头医学院第二附属医院医学检验科,内蒙古包头 014030
2. 格乐大学国际学院公共卫生系,泰国曼谷10220
Keywords: Helicobacter pylori; nodular gastritis; ERM proteins; ezrin
From: Chinese Journal of Comparative Medicine 2024;34(7):150-156
CountryChina
Language:Chinese
Abstract: The ezrin,radixin,moesin(ERM)protein family plays a pivotal role in cell morphology,migration,and signal transduction.Ezrin,as a prominent member of this family,is highly involved in these processes.Ezrin phosphorylation is particularly crucial,by regulating the interaction between ezrin and the actin cytoskeleton.This interaction is a key mediator of cytotoxicity in host cells infected with Helicobacter pylori,significantly impacting cell morphology.In this review,we comprehensively summarize the multifaceted role of ezrin protein in H.pylori-induced nodular gastritis.We consider the relationships between ezrin's structure,function,signaling pathways,and phosphorylation in the context of nodular gastritis.Moreover,this review highlights the role of ezrin protein as a potential therapeutic target,offering novel insights for the prevention and treatment of nodular gastritis.