Research progress on the role of mitochondria-associated membranes in the pathogenesis of Alzheimer's disease
10.3969/j.issn.1671-7856.2024.07.014
- VernacularTitle:线粒体-内质网结构偶联(MAMs)在阿尔茨海默病发病机制中的研究进展
- Author:
Shiyu LIU
1
,
2
;
Yumin XU
;
Hongcai XU
;
Fangmei LU
Author Information
1. 河南中医药大学第一附属医院脑病科,郑州 450000
2. 河南中医药大学第一临床医学院,郑州 450000
- Keywords:
Alzheimer's disease;
mitochondria-associated membranes;
calcium homeostasis;
endoplasmic reticulum stress;
mitophagy;
mitochondrial fusion/fission dynamics;
lipid metabolism;
inflammation
- From:
Chinese Journal of Comparative Medicine
2024;34(7):121-130
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria-associated membranes(MAMs)are a subcellular compartment involved in the communication and material exchange between the mitochondrial outer membrane and endoplasmic reticulum membrane.MAMs perform various biological processes in cells under different conditions.MAM-dysfunction-mediated calcium homeostasis imbalance,endoplasmic reticulum stress,mitophagy defects,mitochondrial fission/fusion dynamics imbalance,lipid metabolism disorders,and inflammatory responses are key pathogenic factors in Alzheimer's disease(AD).This article reviews the structure and function of MAMs,their involvement in AD pathology,and drug intervention targets,and discusses the role of MAMs in the pathogenesis of AD and the latest research into their mechanisms,to provide new ideas for the prevention and treatment of AD.
