Progress of research into the role of miRNA in the pathogenesis of pulmonary hypertension

VernacularTitle:miRNA在肺动脉高压发病机制中的研究进展
Author: Yanjin LI ¹ ; Liying XIAO ; Daoxiong WU ; Rong GUAN ; Chunlang YAN ; Wen LEI
Author Information

1. 昆明医科大学第二附属医院呼吸与危重症医学科,昆明 650106
Keywords: miRNA; pulmonary hypertension; pathogenesis
From: Chinese Journal of Comparative Medicine 2024;34(6):172-178
CountryChina
Language:Chinese
Abstract: Pulmonary hypertension(PH)is a progressive disease characterized by pulmonary vascular remodeling.Current treatments for PH remain suboptimal,and there is an urgent need to better decipher the underlying pathomechanisms to identify new therapeutic targets.MicroRNA(miRNA)are key components in the post-transcriptional machinery that mediates cellular functions and mainly act by regulating the expression of downstream target genes.Numerous in vivo and in vitro studies have demonstrated the involvement of miRNA and their regulators in PH development.However,there is no unified model for the mechanism of miRNA's regulation of pulmonary vascular remodeling.Therefore,this article provides a review on the mechanisms of miRNA in PH characterized in recent years.