Research progress in the benefits of exercise in muscular atrophy based on mitochondrial quality control
10.3969/j.issn.1671-7856.2024.06.019
- VernacularTitle:基于线粒体质量控制探讨运动对骨骼肌萎缩的研究进展
- Author:
Xiaojing GUO
1
;
Yan WANG
;
Li ZHANG
;
Fei PEI
;
Bo ZHANG
;
Huan QIN
;
Shujin WANG
;
Xiaotong LI
Author Information
1. 黑龙江中医药大学,哈尔滨 150040
- Keywords:
muscle atrophy;
exercise;
mitochondrial biogenesis;
mitochondrial dynamics;
mitophagy
- From:
Chinese Journal of Comparative Medicine
2024;34(6):144-150
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle wasting refers to a loss of skeletal muscle mass and function.Mitochondrial quality control(MQC)is the basis by which normal physiological mitochondrial function is maintained and mainly involves the regulation of mitochondrial biogenesis,mitochondrial dynamics(fission/fusion),and mitophagy.MQC maintains muscle homeostasis by regulating the relative stability of mitochondrial shape,quantity,and quality.As an economical and effective treatment for muscular atrophy,exercise interventions are widely used,but the relationship between exercise intervention and MQC is not clear.This paper discusses the role of mitochondrial biogenesis,mitochondrial dynamics,and mitophagy in skeletal muscle atrophy and related molecular targets.We thoroughly analyze the mechanisms by which MQC-mediated exercise can improve the skeletal muscle atrophy caused by aging,disuse,and cancer cachexia in order to provide theoretical guidance for intervention.
