Research progress in the role of ferroptosis in sepsis-associated acute lung injury
10.3969/j.issn.1671-7856.2024.06.017
- VernacularTitle:铁死亡在脓毒症急性肺损伤中的研究进展
- Author:
Yanglin SHI
1
,
2
;
Jianya YANG
;
Qingqing CHANG
;
Qianqian WANG
;
Minghang WANG
;
Suyun LI
Author Information
1. 河南中医药大学第一附属医院呼吸科,郑州 450000
2. 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南省中医药防治呼吸病重点实验室,郑州 450046
- Keywords:
sepsis;
acute lung injury;
ferroptosis
- From:
Chinese Journal of Comparative Medicine
2024;34(6):127-134
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with an extremely high mortality rate,and it is the main risk factor for acute lung injury(ALI).However,the pathophysiology and pathogenesis of sepsis-associated ALI are not fully understood,and effective drugs are extremely limited.Therefore,it is urgent that we explore the pathogenesis of sepsis-associated ALI and attempt to discover effective intervention measures to improve the prognosis of sepsis-associated ALI patients.In recent years,ferroptosis has been considered closely related to the pathological and physiological processes of sepsis-associated ALI,and inhibiting related cell ferroptosis can effectively slow down the occurrence and development of the disease.In this paper,therapeutic strategies targeting ferroptosis in related cells are reviewed to provide a reference for future research on ferroptosis in sepsis-associated ALI and provide a new perspective on potential treatments.
