Progress of research into Notch signaling pathway in liver fibrosis
10.3969/j.issn.1671-7856.2024.06.015
- VernacularTitle:Notch信号通路在肝纤维化中的研究进展
- Author:
Shaoxiu JI
1
;
Hengyao ZHANG
;
Yuan ZHANG
;
Li WEN
Author Information
1. 宁夏医科大学附属银川市中医医院,银川 750001
- Keywords:
Notch signaling pathway;
liver fibrosis;
review
- From:
Chinese Journal of Comparative Medicine
2024;34(6):113-118
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a key pathological process in the progression of chronic liver disease to cirrhosis and even liver cancer.The occurrence of liver fibrosis is a highly integrated and dynamic pathological process result ing from the interactions of many cells and cytokines.The Notch signaling pathway is an evolutionarily conserved intercellular signal transduction mechanism that plays important roles in regulating the development and tissue renewal of multicellular animals.Multiple studies have shown that Notch signal transduction participates in the formation of liver fibrosis in a variety of ways.Therefore,this paper reviews the role of Notch signaling in cells involved in the formation of liver fibrosis to explain the function of this signaling pathway in liver fibrosis.
