Progress of research into mitochondrial mass control system's role in the pathogenesis of septic cardiomyopathy

VernacularTitle:线粒体质量控制系统在脓毒性心肌病发病中的研究进展
Author: Youcheng XIE ¹ ; Shufang XIAO ; Xuemei LIN ; Shun CHEN ; Jin XU ; Fei WANG
Author Information

1. 中国人民解放军联勤保障部队第九四○医院,兰州 730050
Keywords: septic cardiomyopathy; mitochondrial quality control system; mitochondrial biogenesis; mitochondrial fusion and fission; mitochondrial autophagy
From: Chinese Journal of Comparative Medicine 2024;34(6):106-112
CountryChina
Language:Chinese
Abstract: Septic cardiomyopathy(SIC)is an organ dysfunction frequently observed in sepsis and characterized by high mortality and poor prognosis.Understanding the complex pathogenesis of SIC and developing effective therapeutic tools are critical issues that require attention.Previous studies have demonstrated the significant role of mitochondrial dysfunction in the development of SIC.In the presence of SIC,and the mitochondrial dysfunction that result,the aberrant regulation of the mitochondrial quality control system(MQC)can exacerbate cardiomyocyte injury.Recent studies have demonstrated that the MQC maintains the dynamics of mitochondrial homeostasis through its regulation of mitochondrial biogenesis,fusion/fission,and autophagy.This article provides an overview of the role of MQC in SIC pathogenesis,reviews the latest studies in the field,and analyzes MQC's potential as a therapeutic target.