Research progress of SHP2 in digestive system tumors

VernacularTitle:SHP2在消化系统肿瘤中的研究进展
Author: Peng WANG ¹ ; Jianchun FAN ; Juming JIA ; Qingfei DIAO ; Jun XUE ; Xueliang WU
Author Information

1. 河北北方学院,河北张家口 075000
Keywords: SHP2; digestive tract tumor; mechanism of action; clinical study
From: Chinese Journal of Comparative Medicine 2024;34(5):159-168
CountryChina
Language:Chinese
Abstract: Malignant tumors are a major disease threatening human health with disability and mortality rates increasing yearly.Protein tyrosine phosphatase 2(SHP2)of Src homology 2,an important member of the protein tyrosine phosphatase family,has a wide range of functions,and its expression is elevated in a wide range of solid tumors.SHP2 plays an important regulatory role in invasion,metastasis,proliferation,apoptosis,and drug resistance.A large number of studies have shown that SHP2 plays a very important role in the genesis and development of many solid tumors,but no systematic studies have reported on the role of SHP2 in digestive system tumors.Here,we reviewed the biological functions and clinical significance of SHP2 in seven tumor types of the digestive system,explored its roles and mechanisms in cancer development stages,and summarized the development of SHP2 inhibitors to further search for potential targets for effective early diagnosis and gene therapy,which is of great significance to improvement the cancer patient survival rate.