Advances in the study of epigenetic regulatory mechanisms of astrocytes
10.3969/j.issn.1671-7856.2024.05.014
- VernacularTitle:星形胶质细胞表观遗传学调控机制研究进展
- Author:
Liuqing XU
1
;
Peiyuan ZHAO
;
Xihong LIU
;
Xiaodan DU
;
Mengyang FAN
;
Junlin HOU
Author Information
1. 河南中医药大学,郑州 450046
- Keywords:
astrocyte;
epigenetic;
methylation;
histone modification;
non-coding RNA
- From:
Chinese Journal of Comparative Medicine
2024;34(5):126-133
- CountryChina
- Language:Chinese
-
Abstract:
Astrocytes(AS)are the most abundant glial cells in the central nervous system and are involved in many physiological and pathological processes in the nervous system.Alterations in their phenotype are particularly important for the health of the CNS.Epigenetic mechanisms,including DNA methylation,histone modification,non-coding RNA regulation,and chromatin remodeling,are closely linked to alterations in AS proliferation,differentiation,inflammation,and other phenotypic features,but how these mechanisms function needs to be explored and summarized.By reviewing the recent advances in the role of epigenetic mechanisms in AS under various physiological and pathological states,we aim to provide new ideas for the understanding and treatment of related diseases.
