Research progress on the relationship between regulatory cell death and dilated cardiomyopathy
10.3969/j.issn.1671-7856.2024.05.013
- VernacularTitle:调节性细胞死亡在扩张型心肌病中的研究进展
- Author:
Yueqing QIU
1
;
Zhentao WANG
;
Zhenyi CHEN
;
Hongbo CHANG
;
Xiaoyang YU
;
Yikun XUE
Author Information
1. 河南中医药大学第二临床医学院,郑州 450053
- Keywords:
dilated cardiomyopathy;
regulatory cell death;
apoptosis;
necroptosis;
pyroptosis;
autophagy;
ferroptosis;
cuproptosis
- From:
Chinese Journal of Comparative Medicine
2024;34(5):113-125
- CountryChina
- Language:Chinese
-
Abstract:
Dilated cardiomyopathy(DCM)has a concealed onset with left or even whole heart enlargement as the main imaging manifestation.It is a common primary disease of heart failure and arrhythmia.With the continuous deepening of research in recent years,the intrinsic molecular mechanism of regulatory cell death(RCD)has gradually become clear.Researchers have found that the RCD mode plays a very important role in the occurrence and development of DCM.At present,the RCD modes involved in DCM mainly include apoptosis,necrotic apoptosis,pyroptosis,iron death,autophagy,and cuproptosis,and a certain correlation exists among them,which interact and regulate each other.This article provides an overview of the current research status on the mechanisms of the six RCD modes involved in DCM to provide a reference for future basic research and clinical applications.
