Advances in the study of glucose metabolic reprogramming in the pathogenesis of Alzheimer's disease

VernacularTitle:糖代谢重编程在阿尔茨海默病发病机制中的研究进展
Author: Qian XU ¹ ; Qiong YANG ; Zihu TAN
Author Information

1. 湖北中医药大学中医临床学院,武汉 430061
Keywords: Alzheimer's disease; nerve cells; glucose metabolic reprogramming; research progress
From: Chinese Journal of Comparative Medicine 2024;34(4):156-164
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a neurodegenerative disorder characterized by widespread dementia.Despite the extensive research conducted on the pathogenesis of AD over the past 50 years,the underlying mechanisms responsible for AD-related cellular damage and cognitive impairment remain elusive.Multiple studies have confirmed alterations in the glucose metabolism patterns occur within the nerve cells of individuals with AD.This metabolic transition plays a crucial role in cell survival and disease progression,occurring decades before pathological changes and cognitive dysfunction even manifest.This article provides an overview of the potential mechanisms through which glucose metabolism reprogramming contributes to AD development in various types of nerve cells and brain regions,as well as the implication of their interplay.We aim to establish a foundation for further investigations into AD while offering insights and ideas for the development of novel preventive and therapeutic approaches.