Application and research prospects of experimental animal models of chronic stress
10.3969/j.issn.1671-7856.2024.04.018
- VernacularTitle:慢性应激实验动物模型的应用与展望
- Author:
Xiaoqi YUE
1
,
2
;
Yuting LI
;
Miao JIANG
;
Zigang ZHAO
;
Chunyu NIU
Author Information
1. 河北北方学院微循环研究所&基础医学院,河北张家口 075000
2. 河北省急危重症发病机制及干预重点实验室,河北张家口 075000
- Keywords:
chronic stress;
animal model;
evaluation indices
- From:
Chinese Journal of Comparative Medicine
2024;34(4):147-155
- CountryChina
- Language:Chinese
-
Abstract:
The effect and mechanism of chronic stress on psychosomatic diseases are important topics in stress research.The establishment of animal models to simulate human chronic stress is of great significance to investigations of stress responses,the pathogenesis of related diseases,clinical treatment,and drug development.In this paper,animal models of chronic stress commonly used in China and abroad are reviewed;the classification of stressors,animal selection,model construction,pathological manifestations,and evaluation indexes are summarized;and the advantages and disadvantages and application of various models are discussed.The paper provides a reference for the study and selection of models of chronic stress response.
