Research progress on the involvement of macrophages in myocardial ischemia reperfusion injury mediated by NF-κB signaling pathway

VernacularTitle:NF-κB信号通路介导巨噬细胞参与心肌缺血再灌注损伤的研究进展
Author: Shilong LI ¹ ; He WANG ; Yingjie CAO
Author Information

1. 河南中医药大学第一附属医院,心脏中心/国家区域(中医)心血管诊疗中心,郑州 450000
Keywords: myocardial ischemia reperfusion injury; macrophage; NF-κB pathway
From: Chinese Journal of Comparative Medicine 2024;34(4):139-146
CountryChina
Language:Chinese
Abstract: Myocardial ischemia reperfusion injury(MIRI)has become one of the most serious complications affecting the clinical outcome of patients with cardiovascular diseases.The immune inflammatory response of macrophages is closely related to the occurrence and development of MIRI.Many studies have shown that the NF-κB signaling pathway can participate in MIRI regulation by influencing the polarization and inflammatory state of macrophages,pyrodeath,infiltration and other functions,and is a potential target for MIRI therapy.Therefore,this article will review the research progress of NF-κB signaling pathway between macrophage function and MIRI regulation.