Progress of research into pyroptosis in renal ischemia-reperfusion injury

VernacularTitle:细胞焦亡在肾缺血再灌注损伤中的研究进展
Author: Haojie SUN ^{1
,

2} ; Junlei ZHU ; Wei LI ; Suogang WANG
Author Information

1. 河南中医药大学第一附属医院泌尿外科一区,郑州 450003
2. 河南中医药大学第一临床医学院,郑州 450003
Keywords: kidney transplantation; ischemia-reperfusion injury; pyroptosis; inhibitors; intervention means
From: Chinese Journal of Comparative Medicine 2024;34(3):172-178
CountryChina
Language:Chinese
Abstract: Pyroptosis is a programmed cell death mediated by cysteine proteases and is characterized by mitochondrial participation,inflammasome assembly,plasma membrane perforation,and inflammatory release.As an important mechanism mediating the body's inflammatory responses,pyroptosis plays a key role in renal ischemia-reperfusion injury(RIRI).This article reviews the molecular mechanisms of pyroptosis,pyroptotic mechanisms in RIRI,and the progress of research into therapeutic drugs in recent years,with the aim of providing a theoretical reference for the development of early treatments for RIRI.