Etiology,pathogenesis and animal model building of premature ovarian insufficiency

VernacularTitle:卵巢功能不全病因病机及动物模型构建研究进展
Author: Zhihui YANG ¹ ; Yang HU ; Zheng ZONG ; Xiangming SUN ; Hui SONG ; Yingxiang CHEN ; Beilei XU ; Wenjun ZHANG ; Luning CHEN ; Wenlan LI
Author Information

1. 哈尔滨商业大学药学院,哈尔滨 150076
Keywords: premature ovarian insufficiency; animal model; etiology and pathogenesis
From: Chinese Journal of Comparative Medicine 2024;34(3):149-160
CountryChina
Language:Chinese
Abstract: Premature ovarian insufficiency(POI),also known as"ovarian insufficiency",has an incidence of 1％～5％.The incidence has been on the rise in recent years,seriously affecting women's physical and mental health and quality of life.At present,the cause and mechanisms of POI are still unclear,and the method and applications of model construction are also confusing.Most models have some shortcomings in pertinence and stability.The limitations greatly limit research into the clinical diagnosis and treatment of POI.This paper summarizes and discusses the etiology and pathogenesis of POI and the construction of POI animal models to provide a comprehensive reference for those studying POI.