Research progress on the regulation of glutamate in traditional Chinese medicine for treatment of depression
10.3969/j.issn.1671-7856.2024.03.017
- VernacularTitle:中医药调控谷氨酸治疗抑郁症的研究进展
- Author:
Chao LI
1
;
Jian LI
;
Zhenan GAO
;
Mingyu SHEN
;
Jingjing PU
;
Meng WANG
Author Information
1. 华北理工大学中医学院,河北唐山 063210
- Keywords:
traditional Chinese medicine;
depression;
glutamic acid;
research progress
- From:
Chinese Journal of Comparative Medicine
2024;34(3):133-141
- CountryChina
- Language:Chinese
-
Abstract:
Glutamate is a major excitatory neurotransmitter in the central nervous system and a potential neurotoxin.During the development of depression,the glutamate concentration increases in the hippocampus.When glutamate accumulates,it causes serious damage to neurons and brain tissue,aggravating the depressive state.Therefore,glutamate accumulation may be a major mechanism of depression development.Astrocytes,glutamate transporters,and glutamate receptors play important regulatory roles in the glutamate concentration.This article reviews the mechanism-of-action of traditional Chinese medicine on depression by regulating astrocytes,glutamate transporters,and glutamate receptors,and provides new ideas to explore treatment of depression by traditional Chinese medicine.
