Progress of research into natural products that regulate TGF-β1/Smad pathway for the treatment of hepatic fibrosis
10.3969/j.issn.1005-4847.2024.10.010
- VernacularTitle:天然产物调控TGF-β1/Smad通路治疗肝纤维化研究进展
- Author:
Kaiyang LI
1
;
Xiaomei WU
;
Jing HUANG
;
Yun TANG
;
Weixin GUO
;
Qi ZHAO
;
Mei YANG
Author Information
1. 贵州中医药大学,贵阳 550002
- Keywords:
hepatic fibrosis;
TGF-β1/Smad pathway;
natural products;
review
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(10):1320-1331
- CountryChina
- Language:Chinese
-
Abstract:
TGF-β1 is considered a key mediator in the formation of hepatic fibrosis and mainly acts by activating the downstream Smad signaling pathway.Smad2 and Smad3 are two major downstream regulators that promote TGF-β1-mediated tissue fibrosis,while Smad7 is a negative-feedback regulator of the TGF-β1/Smad pathway and inhibits TGF-β1-mediated hepatic fibrosis.A growing number of studies are showing that natural products can delay the progression of hepatic fibrosis by regulating the TGF-β1/Smad pathway,inhibiting HSC activation,and reducing ECM deposition.This article reviews the molecular mechanism of the TGF-β1/Smad signaling pathway in hepatic fibrosis,and summarizes the natural products that target the regulation of this pathway,providing a reference for research into the treatment of hepatic fibrosis.
