Advances in non-surgical animal models of vascular cognitive impairment
10.3969/j.issn.1005-4847.2024.09.014
- VernacularTitle:非手术动物模型在血管性认知障碍中的研究进展
- Author:
Rong SUN
1
;
Zhongnan MAO
;
Xiaodong ZHI
;
Xuexia SONG
;
Shasha LI
;
Shirui ZHANG
Author Information
1. 甘肃中医药大学针灸推拿学院,兰州 730000
- Keywords:
vascular cognitive impairment;
non-surgical animal model;
modeling method;
model mechanism;
model characteristics
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(9):1222-1232
- CountryChina
- Language:Chinese
-
Abstract:
Vascular cognitive impairment(VCI)includes a range of illnesses from mild cognitive impairment to dementia,attributable to cerebrovascular factors.Although appropriate animal models are needed to allow clinicopathological research and drug development,there are currently no animal models that can perfectly simulate the pathogenesis of VCI.At present,carotid artery and vertebral artery stenosis or occlusion are the main method for VCI modeling;however,increasing numbers of non-surgical method have recently emerged,providing new ideas and prospects for the study of this disease.In this paper,we consider the construction method,model mechanisms,and model characteristics of non-surgical animal models of VCI,to provide a reference to help researchers choose the most suitable animal model.
