Progress in the study of animal models of dwarfism

VernacularTitle:侏儒症动物模型研究进展
Author: Yifan LIU ^{1
,

2} ; Nan HUANG ; Yuxuan LIU ; Ling GAN ; Hongyu CHEN
Author Information

1. 重庆市畜牧科学院,重庆 402460
2. 西南大学动物医学院,重庆 402460
Keywords: dwarfism; gene editing; animal model; growth hormone deficiency; chondrodysplasia
From: Acta Laboratorium Animalis Scientia Sinica 2024;32(9):1207-1214
CountryChina
Language:Chinese
Abstract: Dwarfism is a globally rare growth disorder,usually caused by genetics or disease,with the most prominent phenotype being short stature.Animal models are important tools for studying its pathogenesis,prevention,and treatment options,and identifying potential therapeutic targets and biomarkers.The development of genetic engineering technology has greatly promoted the application of gene-edited animal models in the study of dwarfism.In this review,we summarize and discuss the existing animal models of dwarfism in terms of their theoretical basis,model characteristics,and research applications.This offers a reference for researchers and clinicians aiming to better conduct research on the pathogenesis and prevention of dwarfism.