Progress in animal models of sick sinus syndrome
10.3969/j.issn.1005-4847.2024.09.011
- VernacularTitle:病态窦房结综合征动物模型的研究进展
- Author:
Ran SUN
1
;
Guanzhen XU
;
Yue LIU
;
Yingying SUN
;
Shuhan ZHANG
;
Huiying BO
;
Yantong WU
;
Ping HOU
Author Information
1. 辽宁中医药大学,沈阳 110033
- Keywords:
sick sinus syndrome;
animal model;
modeling principle;
heart rate;
research progress
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(9):1198-1206
- CountryChina
- Language:Chinese
-
Abstract:
Sick sinus syndrome(SSS)refers to damage to the sinoatrial node and its surrounding tissues,which leads to excitation and conduction dysfunction of the sinoatrial node,Resultsing in arrhythmia diseases.A better understanding of the pathogenesis of SSS is required to provide a basis for its treatment,including establishing an animal model that can simulate human sinus node dysfunction.In this paper,we review the animal selection,the principles and method of modeling,and the evaluation method and detection indicators of the models,to provide a basis for further studies of the pathogenesis of SSS.
