Progress in the study of bone metastasis in prostate cancer based on a mouse model

VernacularTitle:基于小鼠模型的前列腺癌骨转移机制研究进展
Author: Chenyang ZHANG ^{1
,

2} ; Yaohua HU ; Yanying ZHANG ; Changhong SHI
Author Information

1. 甘肃中医药大学,兰州 730000
2. 空军军医大学实验动物中心,西安 710032
Keywords: prostate cancer; mouse model; tumor metastasis; mechanism studies
From: Acta Laboratorium Animalis Scientia Sinica 2024;32(9):1191-1197
CountryChina
Language:Chinese
Abstract: Prostate cancer is a prevalent malignant tumor in the male genitourinary system,characterized by a high propensity for bone metastasis.It is a leading cause of mortality,with approximately 70％of deaths attributed to this form of metastasis.Mouse models provide a crucial tool in the investigation of prostate cancer bone metastasis,and play a pivotal role in elucidating the underlying pathophysiological mechanisms and in the development and assessment of therapeutic agents.In this review,we summarize research progress in the construction method and evaluation strategies used in establishing prostate cancer bone metastasis mouse models.Notably,this review focuses on the exploration of the mechanisms responsible for prostate cancer bone metastasis,using mouse models,with the aim of offering insights and serving as a valuable reference for prostate cancer bone metastasis.