Review of animal models of non-steroidal anti-inflammatory drug-induced gastric ulcer
10.3969/j.issn.1005-4847.2024.08.016
- VernacularTitle:非甾体抗炎药致胃溃疡动物模型概述
- Author:
Wen WANG
1
;
Yujun HOU
;
Yunzhou SHI
;
Lu WANG
;
Qianhua ZHENG
;
Siyuan ZHOU
;
Ying CHEN
;
Luqiang SUN
;
Shuai CHEN
;
Xiangyun YAN
;
Yanqiu LI
;
Ying LI
Author Information
1. 成都中医药大学针灸推拿学院,成都 610075
- Keywords:
NSAIDs;
indomethacin;
aspirin;
gastric ulcer;
animal model
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(8):1084-1092
- CountryChina
- Language:Chinese
-
Abstract:
Gastric ulcer is a common digestive system disease,and the long-term use of non-steroidal anti-inflammatory drugs(NSAIDs)is the second most important cause.NSAID-induced gastric ulcer animal models are key experimental tools for studying the pathogenesis,corresponding treatment method,and effective mechanisms of NSAID-induced gastrointestinal injury.However,there are currently a lack of reviews on NSAID-induced gastric ulcer animal models.This review summarizes and compares the relevant literature on animal research into indomethacin-and aspirin-induced gastric ulcers in the past 10 years,including the selection of experimental animals,drug solvents,and specific modeling method.The limitations of current models,such as the cumbersome modeling method,incomplete modeling details,inadequate models for clinical use,and lack of comparative drug research,are discussed.Feasible solutions are proposed with the aim of providing an effective reference for research in this field.
