Research progress on experimental animal models of Huntington's disease
10.3969/j.issn.1005-4847.2024.08.014
- VernacularTitle:亨廷顿舞蹈症实验动物模型研究进展
- Author:
Shuo FU
1
;
Wen ZHANG
;
Junke SONG
;
Guanhua DU
Author Information
1. 中国医学科学院药物研究所,北京协和医学院,药物靶点研究与新药筛选北京市重点实验室,北京 100050
- Keywords:
Huntington's disease;
animal model;
model characteristics;
evaluation indicators
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(8):1065-1076
- CountryChina
- Language:Chinese
-
Abstract:
Huntington's disease(HD)is an autosomal dominant neurodegenerative disease,with the main symptoms including chorea-like involuntary movements,psychiatric behavioral abnormalities,and cognitive impairment,which severely affect the lives of patients and consume extensive social and medical resources.Various experimental animal models of HD have been successfully established,to further our understanding of the pathological mechanisms and to explore treatment method of HD.This review outlines the establishment and application of various animal models,ranging from Caenorhabditis elegans,Drosophila melanogaster and zebrafish to mice,rats and miniature pigs,and analyzes the characteristics and advantages of the different models.By reviewing the different animal models and their relevant evaluation indicators,this article emphasizes the importance of utilizing a combination of multiple animal models to promote a deeper understanding of the disease mechanisms and develop effective treatment strategies.
