Overview of behavioral evaluation methods of Parkinson's disease in rat and mouse and analysis of the characteristics of common animal models
10.3969/j.issn.1005-4847.2024.07.013
- VernacularTitle:大小鼠帕金森病行为学评价方法概述及常用动物模型特点分析
- Author:
Yilong HU
1
,
2
;
Yinan ZHAO
;
Jinxin MIAO
;
Mingsan MIAO
Author Information
1. 河南中医药大学,郑州 450046
2. 豫药全产业链研发河南省协同创新中心,郑州 450046
- Keywords:
Parkinson's disease;
rat and mouse;
behavioral experiment;
animal model
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(7):942-954
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease is the second most common neurodegenerative disease in middle-aged and elderly people.It is characterized by a long disease course and complex treatment process,introducing great challenges to society.Behavioral changes in animal models of Parkinson's disease can intuitively reflect the modeling situation of experimental animals and the effects of drug interventions.Therefore,selecting standardized animal models and appropriate behavioral assays is fundamental for both understanding the mechanisms of Parkinson's disease and developing anti-Parkinson drugs.In this paper,we summarize the method of behavioral experiments of Parkinson's disease using mice and rats at home and abroad and systematically summarize the experimental equipment,experimental method,evaluation indexes,and precautions of commonly used Parkinson's behavioral experiments.We also provide an overview of the commonly used animal models of Parkinson's disease and analyze their modeling mechanisms,alignment with the clinical features of Parkinson's disease,and respective advantages and disadvantages.This analysis will help researchers in choosing appropriate animal models of Parkinson's disease and behavioral testing method according to the purpose of the study.
