Research progress on mechanism of necrotizing apoptosis in pancreatic disease
10.3969/j.issn.1005-4847.2024.07.012
- VernacularTitle:坏死性凋亡在胰腺疾病中的作用机制研究进展
- Author:
Runze YANG
1
;
Jing QIN
;
Chenbo GUO
;
Yaohua HU
;
Zhandong WANG
;
Yanying ZHANG
;
Bing SONG
;
Min BAI
;
Changhong SHI
;
Yongfeng WANG
Author Information
1. 甘肃中医药大学基础医学院,兰州 730000
- Keywords:
necroptosis;
acute pancreatitis;
pancreatic cancer;
receptor-interacting protein kinase 1(RIPK1);
receptor-interacting protein kinase 3(RIPK3);
mixed-lineage kinase domain-like(MLKL)
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(7):933-941
- CountryChina
- Language:Chinese
-
Abstract:
Necroptosis is a regulated process of programmed cell death independent of aspartic acid-specific cysteine protease,which can induce inflammation.Studies have shown that necroptosis is closely related to the progression and prognosis of pancreatic disease and plays an important two-way regulatory role in its progression.Related necroptosis inhibitors and inducers are expected to be used in the treatment of pancreatic disease.We herein review the mechanism of necroptosis and its role in the progression of pancreatic disease to provide a new understanding of the pathogenesis and treatment of pancreatic diseases and offer a theoretical basis for the research and development of targeted drugs.
