Advancements in research on the preventive and curative roles of glycyrrhetinic acid and its derivatives in neurodegenerative disease
10.3969/j.issn.1005-4847.2024.07.011
- VernacularTitle:甘草次酸及其衍生物在神经退行性疾病中的防治作用研究进展
- Author:
Yixiao LIU
1
;
Xinyuan HAN
;
Yitong XIAO
;
Xinzhuo YU
;
Tianyuan YE
Author Information
1. 山东中医药大学中医学院,济南 250355
- Keywords:
glycyrrhetinic acid;
derivative;
mechanism of action;
neurodegenerative disease
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(7):923-932
- CountryChina
- Language:Chinese
-
Abstract:
The annual incidence of neurodegenerative disease has been increasing with the aging of the global population,seriously affecting the quality of life of elderly patients and imposing a heavy burden on society.Glycyrrhetinic acid,which inhibits neuroinflammation and protects neurons,is one of the main active ingredients of the traditional Chinese medicine Glycyrrhiza glabra.Increasing numbers of studies are focusing on the mechanism of action of glycyrrhetinic acid and its derivatives in neurodegenerative disease.This review summarizes studies on the effects and mechanisms of action of glycyrrhetinic acid and its derivatives in Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,multiple sclerosis,and cerebellar atrophy.Additionally,the future applications of glycyrrhetinic acid and its derivatives in neurodegenerative disorders are discussed.
