Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus.
10.3346/jkms.2010.25.10.1431
- Author:
You Hyun LEE
1
;
Jung Yoon CHOE
;
Sung Hoon PARK
;
Yong Wook PARK
;
Shin Seok LEE
;
Young Mo KANG
;
Eon Jeong NAM
;
Won PARK
;
Seong Ryul KWON
;
Sang Cheol BAE
;
Yun Jung KIM
;
Chang Hee SUH
;
Hyoun Ah KIM
;
Nam Wook HUR
;
Jisoo LEE
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. leejisoo@ewha.ac.kr
- Publication Type:Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Systemic Lupus Erythematosus, Human Papilloma Virus;
Cervical Cytological Abnormalities
- MeSH:
Adult;
Cervix Uteri/*pathology;
Cross-Sectional Studies;
Female;
Humans;
Lupus Erythematosus, Systemic/*complications/pathology;
Middle Aged;
Odds Ratio;
Papillomavirus Infections/complications/*epidemiology;
Prevalence;
Republic of Korea;
Risk Factors;
Vaginal Smears;
Women
- From:Journal of Korean Medical Science
2010;25(10):1431-1437
- CountryRepublic of Korea
- Language:English
-
Abstract:
We performed a multicenter cross-sectional study of 134 sexually active systemic lupus erythematosus (SLE) patients to investigate the prevalence of and risk factors for high risk human papilloma virus (HPV) infection and cervical cytological abnormalities among Korean women with SLE. In this multicenter cross-sectional study, HPV testing and routine cervical cytologic examination was performed. HPV was typed using a hybrid method or the polymerase chain reaction. Data on 4,595 healthy women were used for comparison. SLE patients had greater prevalence of high-risk HPV infection (24.6% vs. 7.9%, P<0.001, odds ratio 3.8, 95% confidence interval 2.5-5.7) and of abnormal cervical cytology (16.4 vs. 2.8%, P<0.001, OR 4.4, 95% CI 2.5-7.8) compared with controls. SLE itself was identified as independent risk factors for high risk HPV infection among Korean women (OR 3.8, 95% CI 2.5-5.7) along with > or =2 sexual partners (OR 8.5, 95% CI 1.2-61.6), and Pap smear abnormalities (OR 97.3, 95% CI 6.5-1,456.7). High-risk HPV infection and cervical cytological abnormalities were more common among Korean women with SLE than controls. SLE itself may be a risk factor for HPV infection among Korean women, suggesting the importance of close monitoring of HPV infections and abnormal Pap smears in SLE patients.
