Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma.
10.3346/jkms.2010.25.10.1438
- Author:
Li CHEN
1
;
Daiyue YUAN
;
Gui lan WANG
;
You WANG
;
Yuan Yuan WU
;
Jianwei ZHU
Author Information
1. Department of Pathology, Affiliated Hospital, Nantong University, Nantong, China.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Carcinoma, Hepatocellular;
Tspan-1;
Jab1;
p27;
Prognosis
- MeSH:
Adult;
Aged;
Carcinoma, Hepatocellular/metabolism/mortality/*pathology;
Cyclin-Dependent Kinase Inhibitor p27/*metabolism;
Female;
Humans;
Intracellular Signaling Peptides and Proteins/*metabolism;
Liver Neoplasms/metabolism/mortality/*pathology;
Male;
Membrane Proteins/*metabolism;
Middle Aged;
Peptide Hydrolases/*metabolism;
Prognosis;
Survival Rate
- From:Journal of Korean Medical Science
2010;25(10):1438-1442
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases), and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1 suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC.
