Creation and translational relevance of abdominal aortic aneurysm animal models
10.3969/j.issn.1005-4847.2024.04.014
- VernacularTitle:腹主动脉瘤动物模型的研究现状与转化应用
- Author:
Congcong XIA
1
;
Haole LIU
;
Haiwen HOU
;
Enqi LIU
;
Sihai ZHAO
Author Information
1. 西安交通大学医学部实验动物中心,西安 710061
- Keywords:
abdominal aortic aneurysm;
animal model;
porcine pancreatic elastase;
angiotensin Ⅱ
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(4):530-538
- CountryChina
- Language:Chinese
-
Abstract:
Population aging in China has led to an increase in the incidence of abdominal aortic aneurysm(AAA).AAA rupture is one of the most severe life-threatening diseases,with high mortality.The main histopathological features of AAA include elastin degradation,smooth muscle cell depletion,extracellular matrix digestion,and mural leukocyte accumulation.Clinically,drug therapy is still lacking,and open/endovascular repair remains the most effective treatment strategy for AAA management.Notably however,the detailed molecular mechanism of AAA remains unclear,representing an important bottleneck affecting the development of potential drug targets.Animal models are the most powerful tools for clarifying the pathogenesis of AAA,and although some medium-to-large laboratory animal models(e.g.,rabbits,guinea pigs,dogs,pigs)have been established for AAA studies,rodent models(mice and rats)are still the main models used in this field.Current method of inducing AAA include intra-infrarenal aortic infusion of elastase,subcutaneous infusion of angiotensin Ⅱ,periaortic calcium chloride painting,and decellularized aortic xenografting;however,AAA tends to stabilize in most models after ceasing pre-induced stimulation(medical or surgical),and there remains a need for ideal animal models that maintain continuous aortic dilation and even rupture.AAA animal models are helpful for elucidating the pathogenesis of AAA,screening new drug targets,and promoting clinical translation.This review aims to discuss the application of current AAA modeling method and their translational relevance.
