Physicochemical Analysis and Pharmacokinetics of Vanillin from Vanilla planifolia
10.13865/j.cnki.cjbmb.2024.10.1213
- VernacularTitle:香荚兰香草醛的理化分析和药物动力学
- Author:
Meng-Die CHEN
1
;
Ya-Nan WU
;
Ming GUO
;
Jie CHENG
Author Information
1. 浙江农林大学化学与材料工程学院,杭州311300
- Keywords:
Vanilla planifolia;
multispectral technique;
solid phase microextraction gas chromatography-mass spectrometry (SMP-GC-MS);
vanillin (Van)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(11):1596-1607
- CountryChina
- Language:Chinese
-
Abstract:
The medicinal value of vanilla planifolia is of great interest.We analyzed the common princi-pal components of VOCs in different parts of vanilla planifolia,and the human serum albumin (HSA),β-lactoglobulin (β-La) andα-lactalbumin (α-La) were used as template proteins to establish a chain a-nalysis approach with the 'solid phase microextraction gas chromatography-mass spectrometry-multispec-troscopy-physical modelling-pharmacokinetics' (S-M-P-P ) .The mechanisms of the transport and phar-macodynamics for the common principal components of vanilla planifolia were analyzed.The results showed that the common primary VOCs in different parts of vanilla planifolia was vanillin (Van),which attenuated the endogenous fluorescence of HSA/β-La/α-La by static bursting,and formed hydrogen bonds and Van der Waals forces with HSA,and noncovalent complexes with β-La/α-La through hydro-phobic forces.Their interaction facilitates the transport of Van in vivo to intestinal and hepatic tissues and its metabolism by CYP1A2 and CYP2C9 enzymes to exert its pharmacological effects.This study provides a comprehensive and in-depth investigation of the transport mechanisms and pharmacological effects of VOCs from vanilla planifolia,which provides an important reference for understanding the medicinal po-tential of plant derived VOCs.
