The Relationship between Metabolic Syndrome and Intestinal Microbiota:Mechanisms of the Effect of Aerobic Exercise Intervention
10.13865/j.cnki.cjbmb.2024.08.1148
- VernacularTitle:代谢综合征与肠道菌群关系及有氧运动干预效果机制
- Author:
Li WANG
1
;
Zhi-Hao ZHANG
;
Yan-Chun LI
Author Information
1. 北京体育大学,运动人体科学学院运动生物化学教研室,北京100084
- Keywords:
metabolic syndrome (MS);
intestinal flora;
aerobic exercise
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(11):1504-1512
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic syndrome (MS) is a multifaceted metabolic disorder marked by obesity,hyperlipi-demia,liver steatosis,and insulin resistance,posing a significant risk to human well-being.Research on the gut microbiome,metabolites produced by gut microbiota,and their ecological niche has revealed the pivotal role of gut microbiota in the pathogenesis of MS.The advancement of MS is intricately linked to the composition and function of gut microbiota.The gut microbiota and its metabolites have been identi-fied as potential biomarkers for MS,providing early indications of disease progression and offering oppor-tunities for prevention and treatment.Studies have demonstrated that aerobic exercise is a viable and safe intervention for modulating gut microbiota composition.Aerobic exercise has been shown to enhance gut microbiota diversity,regulate metabolites produced by gut bacteria,and strengthen the integrity of the in-testinal mucosal barrier.The implementation of aerobic exercise as an intervention to modulate gut micro-biota has been shown to be efficacious in the prevention of MS by mitigating inflammation,enhancing in-sulin sensitivity,optimizing lipid metabolism,and fortifying the integrity of the intestinal mucosal barrier.This study aims to systematically review the characteristics of gut microbiota in patients with MS,particu-larly those who are obese,diabetic,or have non-alcoholic fatty liver disease.The research will also in-vestigate the correlation between MS and gut microbiota,examine the molecular crosstalk,and assess the impact and mechanisms of aerobic exercise intervention in regulating gut microbiota to prevent MS.The ultimate goal is to offer a novel perspective and potential strategy for using aerobic exercise to modulate gut microbiota and prevent the onset of MS.
