Signalling Pathways and Mechanisms of Linamarin in the Intervention of Disease
10.13865/j.cnki.cjbmb.2024.06.1462
- VernacularTitle:亚麻木酚素在干预疾病中涉及的信号通路及作用机制
- Author:
Xue-Ru YAN
1
;
En-Peng HE
;
Xiao-Di CAI
Author Information
1. 新疆师范大学体育学院运动人体科学重点实验室,乌鲁木齐 830054
- Keywords:
flaxseed lignans;
polyphenols;
anti-inflammatory and antioxidant;
signalling pathways
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(8):1057-1064
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the growing public awareness of personal health has sparked a surge in inter-est in the beneficial effects of polyphenols on the human organism.Extensive research by domestic and international scholars has established that polyphenols,due to their unique chemical properties,exhibit remarkable anti-inflammatory and antioxidant properties,leading to improvements in various diseases,in-cluding cancer,diabetes,and colitis.Notably,China stands as one of the world's largest producers and consumers of flax,a crop rich in lignans,a subclass of polyphenols.These flax lignans possess significant effects on the body,demonstrating immense potential for therapeutic applications.This paper delves into the origins,metabolic processes,and health benefits of flax lignans in China.It offers a comprehensive review of the mechanisms underlying flax lignans role in disease intervention,focusing on their interac-tions with relevant signalling pathways.Our findings suggest that flaxseed lignans can promote organismic health by either directly modulating gene expression or indirectly regulating signalling pathways.Further-more,flaxseed lignans can exhibit diverse effects depending on specific physiological conditions.
