Regulation of Mitochondrial Metabolic Adaptation in Thermogenic Adipocytes
10.13865/j.cnki.cjbmb.2024.05.1432
- VernacularTitle:产热脂肪细胞中线粒体代谢适应的调节
- Author:
Xuan CUI
1
;
Ting SHI
;
Dong-Ning PAN
Author Information
1. 上海交通大学医学院附属第一人民医院临床研究院,上海 200080
- Keywords:
thermogenic adipose tissue;
mitochondrial dynamics;
protein quality control;
cristae;
mito-chondrial stress
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(7):897-906
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of economy and the improvement of human living standard,vari-ous metabolic disorders such as obesity,type 2 diabetes mellitus and non-alcoholic fatty liver disease have become important public health problems in China.Thermogenic adipocytes are rich in mitochondria and uncoupling protein 1(UCP1),which maintain mammalian core body temperature through the consump-tion of triglycerides and glucose and non-shivering thermogenesis.Since activated thermogenic adipocytes are believed to possess anti-obesity and anti-diabetes potential,they have attracted considerable research interests.Mitochondria,as highly functionally conserved organelles in thermogenic adipocytes,respond to alterations in thermogenic capacity through metabolic adaptation in the process of thermogenic activa-tion or inactivation.However,the dysfunction of mitochondrial metabolic adaptation in thermogenic adi-pocytes may result in thermogenic defects and even systemic metabolic disorders.Here,we summarize the recent progress in mitochondrial remodeling in thermogenic adipocytes,including mitochondrial dy-namics,phospholipid and cristae remodeling,and regulation of mitochondrial ROS and oxidative stress.The relevant regulatory factors are summarized,which will provide new insights into how mitochondria maintain thermogenic capacity in thermogenic adipocytes,aiming to help the development of pharmaceuti-cal drugs to activate adaptive thermogenesis for fighting against metabolic diseases.
