Dendritic cell-based immunotherapy for malignant glioma
- VernacularTitle:恶性神经胶质瘤的树突细胞免疫疗法
- Author:
GU JIN-HAI
1
;
LI GANG
Author Information
1. 山东大学齐鲁医院
- Keywords:
dendritic cell;
immunotherapy;
malignant glioma
- From:
Neuroscience Bulletin
2008;24(1):39-44
- CountryChina
- Language:Chinese
-
Abstract:
The immunotherapy for malignant glioma faces unique difficult, due to some anatomical and immunological charac teristics including the existence of blood brain barrier, the absence of lymphatic tissues and dendritic cells (DCs) in the central nervous system (CNS) parenchyma, and the presence of an immunosuppressive microenvironment. Therefore, immunotherapeutic approaches will not be beneficial unless the compromised immune status in malignant glioma patients is overcome. DC based immunotherapy, vaccinating cancer patients with DCs pulsed with various tumor antigens, is one of the most promising immunotherapeutic approaches for treatment of malignant glioma because it seems able to overcome, at least partially, the immunosuppressive state associated with primary malignancies. The preparation of DCs, choice of antigen, and route and schedule of administration are improving and optimizing with rapid development of molecular biology and gene engineering technology. DC vaccination in humans, after a number of pre-clinical models and clinical trials, would increase the clinica lbenefits for malignant glioma immunotherapy.
