Migration and differentiation of bone marrow-derived stem cells in the brain
- VernacularTitle:骨髓源干细胞在脑组织的迁移和分化
- Author:
Zou XI-FENG
1
;
Xu QUN-YUAN
Author Information
1. 首都医科大学
- Keywords:
bone marrow-derived stem cells (BMDSCs);
glia;
neurons;
transdifferentiation;
cell fusion
- From:
Neuroscience Bulletin
2005;21(6):425-431
- CountryChina
- Language:Chinese
-
Abstract:
Whether the bone marrow-derived stem cells (BMDSCs) might migrate into the brain and differentiate there into the neural cells is one of focus of current researches with regard to adult stem cells. There were some studies showing that a certain number of BMDSCs marked with Y chromosome and GFP gene and grafted through the vein of the host animals could be presented in their brain tissue and these migrated cells expressed the specific markers for glial and neuronal cells. There were other studies nevertheless reporting that none of those cells labeled with GFP gene were found in the brain after transplantation through the blood. The causes of such inconsistent results may be due to the times of observation, the methods for labeling the BMDSCs with GFP gene and the gene silence in the brain tissue. As for the integrity of the migrated BMDSCs in the host brain tissue, some experiments showed that they could be differentiated into the glia and neurons by an inducing mechanism from microenviroment in the host brain, while the other experiments proved that the cell fusion might occur between the migrated BMDSCs and the Purkinje cells. The differentiation and fusion of cells may be therefore the two essential ways for the BMDSCs to change their phenotypes from mesoderm to ectoderm. It therefore appears that further study of this matter is necessary to understand the cell replacement in the brain structure maintenance and repair.
