Upregulation of AQP4 expression in the brain of patients with medically intractable epilepsy
- VernacularTitle:药物难治性癫痫患者脑内水通道蛋白-4的表达上调
- Author:
Chen YING-HUI
1
;
Zhao YONG-BO
;
Liu WEN-WEN
;
Guo DENG-JUN
;
Wang NAI-DONG
;
Ma AI-MEI
Author Information
1. 上海市第一人民医院
- Keywords:
medically intractable epilepsy;
aquaporin-4;
brain edema
- From:
Neuroscience Bulletin
2005;21(6):413-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of aquaporin-4(AQP4) in secondary cerebral edema after epilepsy attack. Methods Brain specimens from 18 patients with medically intractable epilepsy and 20 control persons were collected, and the expression of AQP4 in the brain was evaluated by RT-PCR , immunohistochemistry and Western blot. Results Compared with the control group, AQP4 expression in the brain of patients with medically intractable epilepsy showed a statistically significant increase in both mRNA and protein levels (P<0.01). Conclusion AQP4 overexpression in the brain of patients with medically intractable epilepsy may be correlated with secondary cerebral edema after epilepsy attack.
